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Capsy study upgrade#
Capsy study series#

"Squishy helmet," Paradis said with a laugh. Carolina Panthers center Matt Paradis was among about 100 NFL players who arrived for the first padded practice of training camp wearing a large, soft-shelled cover over his helmet that gave him the appearance of a "Star Wars" stormtrooper. Guardian Caps: Are the soft-shelled football helmet covers effective at limiting head injuries?ĬHARLOTTE, N.C.

Capsy study upgrade#

AVISE ® CTD is the only diagnostic test that incorporates CB-CAPs assays, specifically EC4d and BC4d, in a diagnostic panel and is only available from Exagen Inc.You have reached a degraded version of because you're using an unsupported version of Internet Explorer.įor a complete experience, please upgrade or use a supported browser.

Manzi and Ahearn, who helped develop AVISE ® diagnostic testing.

CB-CAPs technology was developed and pioneered by Drs.

The practical application of CB-CAPs as it relates to an SLE diagnostic test was accepted by the American College of Rheumatology (ACR) and presented at the 2011- 2015 ACR scientific meetings.

CB-CAPs technology is accepted and well received within the medical community.

The diagnostic potential of CB-CAPs has been validated in clinical studies and published in peer reviewed journals.

These properties make CB-CAPs ideally suited as biomarkers of SLE. There is also a correlation between the quantification of CB-CAPs and the degree of complement activation.

Cell binding confers stability to these markers because they last for the life of the cells.

Cell-Bound Complement Activation Products (CB-CAPs) are hydrolyzed complement activation products bound to circulating cells such as erythrocytes, platelets, B and T lymphocytes.

In addition to potential as diagnostic biomarkers, the capacity of CAPs to bind covalently to cell surfaces suggested that CB-CAPs might be a fertile source of biomarkers for disease stratification based on the biology of distinct circulating cell types.

C4d has been identified on surfaces of normal erythrocytes, T and B lymphocytes, reticulocytes and platelets.

Capsy study series#

Over the past 15 years, a series of investigations has demonstrated that patients with SLE have substantially higher levels of erythrocyte-bound, lymphocyte-bound, platelet-bound and reticulocyte-bound CAPs than healthy individuals or patients with other inflammatory, autoimmune and rheumatologic diseases.īecause of this, the AVISE ® Lupus and AVISE ® CTD diagnostics were developed using CB-CAPs technology, specifically the EC4d and BC4d markers.ĬB-CAPs were recognized as a potential source of lupus biomarkers for several reasons, one of which was the observation that soluble CAPs might be rapidly hydrolyzed in the circulation or absorbed by cells and/or tissues, making them short lived. C4d has been identified on surfaces of normal erythrocytes, T and B lymphocytes, and reticulocytes. The long history of clinical use of C3 and C4 for the clinical management of patients with lupus, the suboptimal utility of the assays and advances in our understanding of the complement system have led to investigation of Cell-Bound Complement Activation Products (CB-CAPs) as potential biomarkers for a lupus diagnosis.ĬB-CAPs were recognized as a potential source of lupus biomarkers for several reasons, one of which was the observation that soluble CAPs might be rapidly hydrolyzed in the circulation or absorbed by cells and/or tissues, making them short lived.